Half-life – 3 hr (qin geriatric patients and patients with hepatic impairment). TIME/ACTION PROFILE (sedation). ROUTE. ONSET. PEAK*. DURATION. enavody.eug: hydromorphone hydrochloride. Hydromorph Contin: Hydromorphone controlled-release belongs to the family of CONTIN and the strength 3 mg , contains hydromorphone HCl 3 mg. If it is almost time for your next dose, skip the missed dose and continue with . tricyclic antidepressants (e.g., amitriptyline, desipramine); warfarin; zolpidem; zopiclone. Dilaudid/Hydromorphone Hydrochloride Oral Tab: 2mg, 4mg, 8mg In patients receiving opioids, both the dose and duration of analgesia will vary substantially Zolpidem: (Moderate) Concomitant use of hydromorphone with zolpidem can.