Polysorbate 80 is made from natural sorbitol and plant-based oleic acid, is used in a wide variety of foods, medicines, and vitamin supplements, and is included in the Handbook of Green Chemicals. Requires that parents commit to giving at least three doses or weekly doses What are the current recommendations for giving Vitamin K? Enzyme cofactors. Pharmacogenetics of vitamin K antagonists: useful or hype? FEBS Letters. Vitamin K deficiency has been defined as a vitamin K-responsive hypoprothrombinemia which increase prothrombin time  and thus can result in coagulopathy, a bleeding disorder. All of the infants were exclusively breastfed, and they all had critically low levels of Vitamin K in their blood. Some parents have concerns about use of the propylene glycol.
Vitamin K deficiency bleeding, thought to be a problem of the past—has been recently thrust back into the spotlight. The infants were diagnosed with late Vitamin K deficiency bleeding VKDB —four of the infants had bleeding in the brain, and two had bleeding in the intestines. Although the six infants survived, two required emergency brain surgery to save their lives, one has severe brain damage a stroke with right-sided paralysis and severe cognitive delays, and two have mild to moderate brain injuries Schulte et al.
The Canadian Paediatric Society gives permission to print single copies of this document from our website. For permission to reprint or reproduce multiple copies, please see our copyright policy. Eugene Ng, Amanda D. Loewy, Fetus and Newborn Committee.
Since , the American Academy of Pediatrics has recommended supplementing low levels of vitamin K in newborns with a single shot of vitamin K given at birth. Low levels of vitamin K can lead to dangerous bleeding in newborns and infants. The vitamin K given at birth provides protection against bleeding that could occur because of low levels of this essential vitamin. Below are some commonly asked questions and their answers. If you continue to have concerns about vitamin K, please talk to your pediatrician or healthcare provider. A: Vitamin K is used by the body to form clots and to stop bleeding. Babies are born with very little vitamin K stored in their bodies. VKDB is a serious and potentially life-threatening cause of bleeding in infants up to 6 months of age.